Wonder how I missed this thread yesterday. Anyway, something that alot of us do (and I'm probably most guilty with this) is not thinking about other collectors

There is a group of collectors that collect original government packaged mint sets. There are other collectors that collect rolls of proof and uncirculated coins, which more oft comes from these government packaged mint sets. And there are those that collect dead/entombed coins. In order to obtain the highest quality samples to get the most profitable casket out there, many original government mint sets are broken apart and coins sent en masse to the butchers for slaughter, autopsy, embalming, and eventual entombing.
There are already so many people buying up and breaking apart original government mint sets, that one more person won't make that much of a difference in the current populations, right?

Just something to think about.
Anyway, do what you want! (Lord knows, I do!) But, I would have to actually disagree to a point with everyone about the economics of it. If you consider time = money, then, yes, buying the set
may be more econnomical, but not necessarily.
Let's take the 2003 sets, for instance. The silver set is going to cost you about $35 (plus shipping) from a dealer, quick and easy. If you spend more time (thus more "money"), you could win a set off eBay for around $30, shipped. And if you look on eBay for the SQs only, you could grab them for around $20 plus shipping. The singles are selling for around $3-$4 each, plus shipping, making it about $15-$20 plus shipping per year set.
Now, other than actually buying the set from a dealer, the other options all require an amount of time ("money"), as well as the time ("money") of breaking them apart. Also, the time ("money") and money it requires to offload the "extras" you end up with also need to be considered. Personally, I believe that bidding out for proof singles would be your most economical choice in both time and money, because you will be forwarding out about only 60% upfront for the coins compared to using a dealer, and you have no further extra time or money in breaking the sets and offloading your extras. So, you could virtually fill twice as many holes with the same amount of funds.
Part of the fun in this hobby, for me, is the thrill of the hunt. If all it took was money and it would be yours, there's no fun in that. Even when it takes months on end to find that certain coin or set, it makes it all that much more appreciable when I finally do get it!
But, just do what makes you happy!

Just some food for thought.